Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromso Study

Source: Lerstad G et al J Thromb Haemost. 2013 Dec 30. doi: 10.1111/jth.12498.
Organisation: Hematological research group (HERG).

Hyperglycemia Venous Thromboembolism Venous Thrombosis

Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. OBJECTIVES: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. METHODS: HbA1c was measured in 16 156 unique subjects (25-87 years) who participated in one or more surveys of the Tromso study (Tromso 4; 1994-95, Tromso 5; 2001-2, and Tromso 6; 2007-8). All subjects were followed, and incident VTE events were recorded through December 31, 2010. RESULTS: There were 333 validated first VTE events, of which 137 were unprovoked, during a median follow-up of 7.1 years. HbA1c was not associated with future risk of VTE in analysis treating HbA1c as a continuous variable, or in categorized analyses. The risk of VTE increased by 5% per 1 SD (0.7%) increase in HbA1c (multivariable-adjusted HR 1.05; 95% CI 0.97-1.14), and subjects with HbA1c >/= 6.5% had 27% higher risk compared to those with HbA1c below 5.7% (multivariable-adjusted HR 1.27; 95% CI 0.72-2.26). There was no significant linear trend for increased risk of VTE across categories of HbA1c (p=0.27). CONCLUSIONS: Serum levels of HbA1c were not associated with future risk of VTE in multivariable analysis. Our findings suggest that hyperglycemia does not play an important role in the pathogenesis of VTE. This article is protected by copyright. All rights reserved

Click Here To Read More 
Keywords:
Medline  Literature Alert  


Other Topics Mentioned:

hemoglobin



   abstracted provided by MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

Article Toolkit

More Stories Like This. Click to see other articles in this area.
Read article in Utopia Documents, the revolutionary new way to read scientific papers that integrates directly with SciBite
Extract Chemical Structures, Via the Chemicalize from ChemAxon service*.
Report An Error. If you think this article is incorrectly tagged or missing something let us know!

* Denotes third party service. SciBite is not responsible for any third party service.

Altmetric Ranking

Altmetric tracks article mentions across social media. This articles Altmetric score is:

Location Info

Not Available

Sponsored Links