The CD40 CD40L system: A new therapeutic target for disease

Source: Zhang B et al Immunol Lett. 2013 Jul 25. pii: S0165-2478(13)00097-7. doi: 10.1016/j.imlet.2013.07.005.
Organisation: Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

CD40 ligand CD40 molecule, TNF receptor su.. cd antigen tnf receptor

The role of CD40/CD40 ligand (CD40L) interactions in atherothrombosis, in the response of the immune system to pathogens and in thrombosis is now widely accepted. A role for CD40-CD40L interactions has been identified in atherosclerosis (AS), and such interactions are known to destabilize atherosclerotic plaques by inducing the expression of cytokines, chemokines, growth factors, matrix metalloproteinases and pro-coagulant factors. CD40/CD40L interactions have also been implicated in immune system disorders. Recent studies have suggested that CD40/CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and the cardiovascular systems. Here, we discuss the current drugs that target the CD40/CD40Lsystem, as understanding the roles and regulations of CD40/CD40L-mediated signal pathways by these drugs could facilitate the development of therapeutics that target diverse diseases
Keywords:
MHDA- 2013/07/31 06:00    Medline  Literature Alert  New Mechanism  Gene-Gene Link  Gene-Disease Link  
Relevant Pathways

This article mentions proteins present in the following molecular pathways (click to explore):

 Immunoregulatory Interactions ..
 BETA2 Integrin Cell Surface In..
 Nlr Proteins
 CD40/Cd40l Signaling
 Inflammatory Response Pathway
 CALCINEURIN‑Regulated NFAT‑Dep..
 TOLL‑Like Receptor Signaling P..
 Calcium Signaling In The CD4+ ..
 Regulation Of TOLL‑Like Recept..
 IL4‑Mediated Signaling Events
 Cd40l Signaling Pathway


Other Topics Mentioned:

Atherosclerotic Plaque Atherosclerosis Thrombosis cytokine matrix metalloproteinase chemokine



   abstracted provided by MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

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